Friday, 18 September 2020

PharmAbcine, SLBio to evaluate combination therapy to treat NSCLC

05 August 2020 | News

Partnership to evaluate the combination of olinvacimab and C-005, the 3rd generation of EGFR inhibitor with superior brain-blood-barrier permeability, in treating non-small cell lung cancer (NSCLC)

Photo Credit: Freepik

Photo Credit: Freepik

South Korean firm PharmAbcine Inc. entered into a research collaboration with Wuxi Shuangliang Biotechnology (SLBio) to evaluate the combination of each party's clinical candidate, olinvacimab and C-005, the 3rd generation of EGFR inhibitor with superior brain-blood-barrier permeability, in treating non-small cell lung cancer (NSCLC). NSCLC is the leading cause of cancer-related deaths in the US and China.

Olinvacimab, the leading clinical candidate being developed by PharmAbcine, has shown an impressive safety profile and efficacy in clinical studies. It is currently in phase II clinical trial in Australia and the USA in bevacizumab non-responding rGBM patients. In addition, two-phase Ib combination trials of olinvacimab and pembrolizumab are ongoing in mTNBC and in rGBM patients. It has been shown in the previous rGBM phase IIa trial that numerous rGBM patients have improved their cerebral edema condition by olinvacimab treatment.

C-005, the leading clinical candidate being developed by SLBio, is a novel 3rd-generation EGFR inhibitor. Pre-clinical studies have shown C-005 has strong BBB penetrating properties and best-in-class safety profile. Ph I clinical trial in China was ongoing in EGFRm+ NSCLC patients. Preliminary Ph I data have demonstrated promising efficacy and safety profiles.

"Over 40% of NSCLC patients would develop CNS metastases including brain and leptomeningeal metastases in their life span," said Dr. Jiaquan Wu, CEO of SLBio. "C-005 has shown superior brain-blood-barrier penetration properties and excellent safety profiles in pre-clinical models. It would provide metastatic lung cancer patients with a better treatment option. Combination with anti-angiogenensis agents including Olinvacimab would further benefit our patients. We are excited about the opportunity to work with PharmAbcine."     

"Previous combination therapies of EGFR and VEGFR-2 inhibitors did not yield fruitful results because of drug related adverse effects such as cardiovascular problems," said Dr. Jin-San Yoo, CEO of PharmAbcine. "We believe that the combination of the two agents may lead to a more effective therapy to treat NSCLS, especially the patients with brain metastasis. This study will give us a tremendous opportunity to explore an optimal combination of angiogenesis regulator and 3rd generation EGFR inhibitor to treat NSCLC."

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