Singapore - Results from a Phase 3 clinical trial, IMpassion130, evaluating Roche unit Genentech's TECENTRIQ (atezolizumab) plus Celgene's ABRAXANE (nab-paclitaxel) in patients with unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) showed a treatment effect. The data were presented at ESMO in Munich.
Patients receiving the combination showed median progression-free survival (PFS) of 7.2 months compared to 5.5 months for ABRAXANE alone. The separation was statistically significant.
In a subgroup of PD-L1-positive patients, median PFS also favored the combination, 7.5 months versus 5.0 months.
Median overall survival (OS) favored the combo (21.3 months versus 17.6 months) in the intent-to-treat population but the separation was not statistically valid (p=0.0840). The combo extended OS 9.5 months In the PD-L1-positive population.
Development is ongoing.
TNBC, comprising 15% of all breast cancer cases, is more aggressive and treatment-resistant since the cancer does not express receptors for targeted therapies.
