About the webinar
Protein A chromatography remains the dominant capture step for monoclonal antibody purification, but its cost is under increasing scrutiny as upstream titres rise and commercial manufacturing becomes more cost-sensitive.
Two main strategies can reduce capture cost: lowering upfront resin cost or extending usable resin lifetime. This work examines how these approaches influence effective cost per gram of purified antibody, with focus on key technical factors.
The lowest-priced resin is not always the most economical option.
These findings support a more application-specific approach to Protein A resin selection to reduce cost of goods in commercial mAb manufacturing. Attendees will gain insights into the technical factors that influence Protein A resin value, supporting a more application-specific approach to resin selection.
Two routes to a lower cost per gram
Pathway 1: Lower upfront resin cost
Cut the purchase price of the capture step by selecting a lower-cost Protein A resin. The webinar's modelling analysis examines when this genuinely lowers the effective cost per gram of purified antibody, and when hidden performance trade-offs erode the saving.
Key question: does the cheaper resin's performance still align with your process needs?
Pathway 2: Extend usable resin lifetime
Intensify the process by getting more cycles from every litre of resin. Cleaning strategy and campaign length become decisive factors, and the modelling shows how lifetime extension changes the economics across a commercial campaign.
Key question: how do cleaning strategy and campaign length shape resin value over time?
Five things you will take away
Total value is determined by performance, lifetime, and productivity.
Reduce resin spend or intensify the process.
It continues to shape cost of goods in commercial mAb manufacturing.
Application-specific analysis outperforms a generic purchasing rule.
Register to learn how to make that match for your own operation.
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