13 Jun 2013, BioSpectrum Bureau , BioSpectrum
Singapore: A new research conducted by Rutgers University and Oregon State University have revealed that inhalation of chemotherapy reduces systemic damage done to healthy lung cells and other organs while improving the treatment of lung tumors. The research has been published in the Journal of Controlled Release.
With conventional chemotherapy treatment for lung cancer, the drugs tend to accumulate in the liver, kidney, and spleen, with less making it to the lungs. But in the new study, 83 percent of the drugs delivered via inhalation therapy, as compared to 23 percent with the intravenous injection, were delivered directly to the lungs and predominantly accumulated in tumor cells.
Researchers were able to enhance the efficacy of lung cancer treatment by using a combination of tiny nanoparticles of existing cancer drugs and small interfering molecules that shut down the ability of the cancer cells to resist attack. In the four-month animal study the lung tumors in mice that were treated with inhalation therapy, virtually disappeared.
Dr Tamara Minko, professor and chair, department of pharmaceutics, Rutgers, "The development of additional more effective and safe approaches to treatment of this disease is vitally important. Up until now, limited clinical efficiency and significant toxicity have represented two critical barriers restricting progress in the therapy of advanced lung cancer."
He added, "The proposed novel treatment much more effectively killed resistant cancer cells when compared with conventional anti-cancer drugs and showed superior efficiency over the traditional chemotherapy."