Singapore, Jan 21, 2010: Drug major Daiichi Sankyo has received approval in Japan to manufacture and market Rezaltas combination tablets LD and HD for the treatment of hypertension.

Rezaltas is a combination drug featuring the Daiichi Sankyo-developed olmesartan medoxomil (Olmetec), a high-affinity ARB (angiotensin receptor blocker), and azelnidipine (Calblock), a long-acting CCB (calcium channel blocker) that the company researched and developed with Ube Industries, Limited. The LD tablet incorporates 10mg of olmesartan medoxomil and 8mg of azelnidipine. The HD tablet employs 20mg and 16 mg, respectively, of these substances.

ARBs and CCBs are often prescribed together in Japan because they address the multiple causes of hypertension in order to reduce blood pressure to target levels. Daiichi Sankyo has combined olmesartan medoxomil, which has proven exceptionally powerful in lowering blood pressure among ARBs, with azelnidipine, a CCB that delivers ongoing decreases in blood pressure while minimizing sympathomimetic hyperactivity. Clinical studies demonstrated that Rezaltas consistently suppresses blood pressure for 24 hours while offering excellent tolerance, noted the company release.