• Australia
  • 10 August 2012
  • Opinion
  • By Dr G-Halli Rajasekariah & Dr Hubert G Mazure

Customizing kits for diagnosis of infectious diseases

Updated on 10 August 2012

Our portfolio of specialist products cover medical problems in the developed and underdeveloped worlds. Rather than developing high revenue earning products, Cellabs wanted to focus on greater world problems and help patients in the low economic worlds. We provide high quality testing kits for reliable diagnosis of infectious diseases across the world.

With an objective to develop custom-made kits for infectious diseases, we work with the Walter Reed Army Institute of Medical Research, Maryland, US, to develop a complete panel of diagnostic devices for leishmania infection.

At Cellabs, we have made progress towards the identification of people, who are exposed to malaria before the appearance of symptoms. We have developed a reliable malaria antibody diagnostic test to assess exposure to malaria. This assay, called Pan Malaria Antibody, CELISA, detects exposure to all four main species of human malaria including P. falciparum, P. vivax, P. malariae and P. ovale, of which the first three are relevant to India.

This assay could be useful in Indian regions that are non-endemic for malaria, in order to assess whether local people are exposed to the infection or not and to help control seasonal malaria outbreaks following the monsoon rains. Indians move around in significant numbers for festivals, business or pilgrimages. Such movements of population from non-endemic to endemic regions often result in travellers being exposed to malaria.

Cellabs has recently developed a novel and highly sensitive invitro diagnostic test to overcome the shortfalls of traditional Giemsa microscopy. The Rapimal-FA test is a direct immuno fluorescence microscopic test where a monoclonal antibody labelled with a fluorescent dye (FITC) is used to stain directly, the malaria parasites in blood smears. We have also developed another immuno fluorescence test for malaria targeting P. vivax parasites. These two immuno fluorescence tests are useful for analyzing blood smears of actual malaria parasites. They provide a simpler, quicker and more reliable way to diagnose malaria infection than conventional Giemsa microscopy, even at low parasitemia.

Cellabs has also recently developed another in vitro diagnostic test for malaria that is ideally suited for use in blood banks and which provides a highly sensitive detection even at low parasitemia, where conventional Giemsa microscopy commonly fails to provide a reliable diagnosis. This new assay, Quantimal pLDH CELISA, can measure the number of malaria parasites in infected patient blood samples down to a few parasites, per microlitre of blood.

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