Updated on 30 August 2012
EMA401 is being developed as a potential first -in-class oral treatment for neuropathic pain and related symptoms without central nervous system side effects. In addition to PHN, Spinifex's clinical program for EMA401 includes a phase II study in the treatment of neuropathic pain in cancer chemotherapy patients and this trial is currently recruiting.
In addition to positive phase II results, EMA401 has shown efficacy in a number of relevant pre-clinical models and good human safety and pharmacokinetics in phase I studies. Spinifex continues to conduct research into the role of the AT2 receptor in nociceptive, inflammatory and neuropathic pain states and these fundamental studies support not only the EMA401 clinical program but also Spinifex's ongoing AT2 receptor antagonist drug discovery program.