Updated on 1 October 2012
The HIBM phase I clinical trial will test a single dose of DEX-M74 in a small group of patients with a focus on drug safety and how patients tolerate the drug. Dr Nuria Carrillo, TRND staff physician and principal investigator of the HIBM phase I trial, plans to follow-up with a phase IIa trial in which patients will receive multiple doses of DEX-M74. Researchers will monitor patients for drug tolerance and indications of drug effectiveness as well.
Mr Andy Lewis, CEO of NZP, expressed his gratitude that the TRND supported program has started and acknowledges with thanks the huge effort the NHGRI, the Clinical Center and the NCATS teams put into the program. "The NIH has achieved a significant milestone in the development of a potential treatment for HIBM and we are excited about this research reaching the clinical trial stage. The pre-clinical data is very strong and we are keen to see DEX-M74 progress through the Clinical Phases".
NZP holds the NIH license to take DEX-M74 forward when safety and proof of efficacy have been achieved for HIBM and glomerular kidney diseases.