Updated on 17 March 2017
Genomic Health announced the presentation of 15 abstracts for the Oncotype DX breast cancer test at the 15th St Gallen International Breast Cancer Conference in Vienna, Austria.
This test uses genomic analysis techniques to uncover the unique footprint of each patient's tumour and generates a Recurrence Score result which predicts the likelihood that the patient's cancer will return and whether chemotherapy is likely to provide benefit.
The presentations underline the substantial real world evidence which is now available for Oncotype DX and reflect the growing adoption of the test across Europe to personalise and improve the quality of clinical decisions leading to better patient outcomes and more cost-effective treatment.
Data highlights include:
"The traditional criteria used for making chemotherapy clinical decisions may result in substantial overtreatment and toxicity with unnecessary costs for healthcare systems. The decision to initiate a course of chemotherapy should be as informed as possible. From a health service perspective, it is costly and resource-intensive but the toll for the patient can be even greater," said Prof. Joseph Gligorov, Breast Cancer Expert Center, APHP-Tenon Hospital, Paris. "The new evidence presented for the Oncotype DX test highlights the impact it is having across Europe to drive a step-change in the quality of treatment decisions. These results, based on real-world clinical practice, indicate that molecular testing provides clinically meaningful information in addition to classical pathological parameters for a significant proportion of patients and support its broader use and public reimbursement."
Every year in Europe, over 490,000 new cases of breast cancer are diagnosed. It is the most common cancer in women and affects many of them during their years dedicated to working and raising a family. An average of 20% of breast cancer cases in Europe occur in women when they are younger than 50 years old; and 37% occur at age 50-64. While chemotherapy is routinely offered, research shows that less than 10% of patients with early-stage breast cancer actually benefit from it.