Updated on 9 April 2015
WaVe Life Sciences has appointed Roberto Guerciolini, M.D., as Senior Vice President and Head of Early Development. He was most recently Vice President and Product General Manager at Shire and WaVe claims that he brings tremendous biopharmaceutical research and development experience from lead identification through clinical development across multiple therapeutic areas.
Dr. Guerciolini will lead WaVe Life Sciences' translational and early clinical activities as the company advances a pipeline of stereopure nucleic acid drug candidates across multiple disease areas.
At Shire AG, a division of Shire plc in Switzerland, Dr. Guerciolini was responsible for building an early-stage pipeline for its Specialty Pharmaceuticals group. Prior to Shire, he was Senior Vice President of Pharmaceutical Development at Dicerna, a company which he co-founded. Previously, he was Senior Vice President of Development and Chief Medical Officer of Sirna Therapeutics, which was acquired by Merck & Co. in 2006.
At Sirna, he led clinical development activities and regulatory affairs, conducting the first ever clinical trial with a chemically optimized siRNA. Prior to Sirna, he was Senior Director of Clinical Pharmacology and Experimental Medicine at Millennium Pharmaceuticals, where he was responsible for overseeing the conduct of early stage clinical trials in the areas of oncology, inflammation and metabolic diseases. While at Millennium, he also significantly contributed toward the successful filing of an NDA for Velcade.
Prior to this, he served in clinical development at Roche, where he played an important role in the filing and registration of Xenical in the U.S. and Europe, as well as at Schering-Plough Corporation. Dr. Guerciolini received his Medical degree and Board certification in Internal Medicine from the University of Perugia Medical School in Italy. He completed a postdoctoral fellowship in Clinical Pharmacology at the Mayo Clinic and is certified by the American Board of Clinical Pharmacology. Dr. Guerciolini additionally earned an executive MBA from the Haas School of Business, University of California-Berkeley.