Updated on 8 January 2015
Kyowa Hakko Kirin is planning to initiate clinical trials in 2015
Singapore: Japanese company, Kyowa Hakko Kirin and Korean firm, Syndax Pharmaceuticals, have entered into a license agreement for the exclusive rights to develop and commercialize entinostat in Japan and Korea.
Entinostat is a Class I selective histone deacetylase (HDAC) inhibitor being developed by Syndax in the United States and Europe in combination with hormone therapy for advanced breast cancer and immune therapy combinations in solid tumors.
Kyowa Hakko Kirin will pay Syndax a total of up to $100 million including an upfront fee of $25 million with a certain amount of an equity investment and potential development and commercial milestone payments. Syndax will manufacture and supply the product to Kyowa Hakko Kirin during the term of the agreement.
"We are pleased to enter into a partnership with Syndax to develop Entinostat in Japan and Korea. Entinostat has great potential to treat a cancer with a mode of action modifying epigenetics," stated Dr Masashi Miyamoto, executive officer, director, strategic product portfolio department, Kyowa Hakko Kirin. "We believe that Entinostat could deliver a lot of benefit to breast and other cancer patients, which lead to strengthen KHK's future oncology portfolio."
Mr Arlene Morris, president and chief executive officer, Syndax, said, "Since we have already begun a registration-directed Phase 3 trial in breast cancer in the US, it's important and timely to enter into this agreement with KHK to initiate development in order to bring entinostat to breast cancer patients in Japan and Korea.
Kyowa Hakko Kirin is planning to initiate clinical trials in 2015.