Updated on 29 December 2014
The next step in research is to tackle the issue of treatment, says researcher
Singapore: According to a recent research at Taiwan based National Cheng Kung University (NCKU), obesity leads to a reduction in the protein lysyl oxidase (LOX) which accelerates aortic aging and stiffness, causing arteriosclerosis, and is a major threat to health.
Professor Yau-Sheng Tsai of the NCKU Institute of Clinical Medicine led the team to investigate the pathophysiological link between arteriosclerosis and obesity.
Through experimentation, the team found that obesity leads to a decrease in LOX expression, which subsequently reduces elastic fiber strength and the level of cross-linkage. Consequently, it increases elastin fragmentation and elastolytic activity.
It was also noted that the aortas of obese mice were surrounded by a significant amount of pro-inflammatory and pro-oxidative perivascular adipose tissue.
In vitro studies revealed that the conditioned medium from differentiated adipocytes or the perivascular adipose tissue of obese mice decreases LOX activity.