Updated on 16 December 2014
Cantrixil has been developed jointly by Novogen and Yale University
Singapore: Cantrixil, a first-in-class experimental chemotherapeutic, developed by Australia/US-based biotech firm Novogenis, is due to enter a first-in-man clinical study in 2015.
Cantrixil is a cytotoxic chemotherapy to be developed specifically for injection into the body's cavities. The peritoneal and pleural cavities are involved in a large proportion of cancers, and yet the vast majority of chemotherapies continue to be administered in a way that delivers chemotherapies to the cancer via the bloodstream.
Delivering the drug directly into the cavity where the cancer is spreading ensures cancer cells are exposed to levels of drug some hundreds of times greater than via the blood.
Cantrixil has been developed jointly by Novogen and Yale University and is owned by their joint-venture company, CanTx Inc.
Cantrixil is a construct of active drug candidate, TRXE-002, in a cyclodextrin shell. On injection into the cavity, the shell dissolves to release the active drug. Cantrixil has been designed to be non-irritant and to not be dose-limiting due to side-effects.