Updated on 3 July 2012
The scientists are hopeful that this ATM-mTor pathway could similarly map onto cancer to suppress tumour progression. Similar to suppression of obesity and atherosclerosis, activation of autophagy in cancer cells could result in degradation of cellular content that is essential for cancer cells to sustain rapid proliferation. This, in turn, will result in suppression of cancer growth.
Dr Dmitry Bulavin said, "We are building on this research to investigate if the same mechanism could also control tumour progression and hence potentially unlock new therapeutic treatments targeting Wip1, ATM and mTor in cancer as well and the preliminary results are promising."