Updated on 18 December 2013
The need for a for a new anaesthetic that is both safe and effective continues to grow significantly with more than 80 million general anaesthesia procedures performed annually in the United States and Europe alone.
Although propofol is commonly used in anaesthesia, there are significant problems associated with its use including: a propensity to cause falls in blood pressure, depression of breathing, the lipid based preparation is easily contaminated and supports bacterial growth; is incompatible with plastic containers and leads to lipid toxicity.
Phaxan has none of these problems when tested in preclinical studies. The active pharmaceutical ingredient in Phaxan, alphaxalone, has been administered previously to humans as Althesin, which was withdrawn from the market due to allergic reactions caused by the excipient. By changing the excipient in the formulation, Phaxan overcomes this issue and Drawbridge looks forward to re-introducing alphaxalone to the market as Phaxan.