Updated on 12 November 2013
Seoul: Boehringer Ingelheim and Eli Lilly & Company have announced new data that reinforces the efficacy and tolerability of linagliptin in patients with Type 2 Diabetes (T2D) and liver disease, as well as in Asians with T2D (65 years and older). The data adds to a growing body of clinical evidence supporting the use of linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor from Boehringer Ingelheim (BI) and Eli Lilly and Company, in a broad range of adults with T2D.
The data was shared at the 2013 International Conference on Diabetes and Metabolism & 5th Asian Association for the Study of Diabetes (AASD) Annual Scientific meeting held in Seoul, South Korea.
The US Food and Drug Administration (FDA), European Medicines Agency (EMA), Japan Pharmaceuticals and Medical Devices Agency (PMDA) and several other regulatory authorities worldwide have approved linagliptin for the treatment of adults with T2D as monotherapy or in combination with metformin, metformin + sulphonylurea, and as add-on therapy to insulin. With linagliptin, no dose adjustment is required regardless of renal function or hepatic impairment.
Adults with T2D, aged 65 years or older, and those with pre-existing liver and biliary disease are characterized by limited treatment options. With the rate of T2D rapidly growing in Asia, and the prevalence of T2D and hepatobiliary diseases being high, especially in Asian countries, effective and safe treatment options are increasingly becoming a priority. Given the major elimination of linagliptin via the entero-hepatic system, further characterizing the efficacy and safety of linagliptin in T2D patients with liver and biliary complications becomes particularly important.