Updated on 17 October 2013
Dr Wang's group used a combination of genetic engineering and fluorescent tags delivered by viruses to color-code four different kinds of neurons and map their connections.
Singapore: Human fingertips have several types of sensory neurons that are responsible for relaying touch signals to the central nervous system. Scientists have long believed these neurons followed a linear path to the brain with a "labeled-lines" structure.
But new research on mouse whiskers from Duke University reveals a surprise- at the fine scale, the sensory system's wiring diagram does not have a set pattern. And it is probably the case that no two people's touch sensory systems are wired exactly the same at the detailed level, according to Dr Fan Wang, an associate professor of neurobiology in the Duke Medical School.
The results, which appear online in Cell Reports, highlight a "one-to-many, many-to-one" nerve connectivity strategy. Single neurons send signals to multiple potential secondary neurons, just as signals from many neurons can converge onto a secondary neuron. Many such connections are likely formed by chance, Dr Wang said. This connectivity scheme allows the touch system to have many possible combinations to encode a large repertoire of textures and forms.
"We take our sense of touch for granted," Dr Wang said. "When you speak, you are not aware of the constant tactile feedback from your tongue and teeth. Without such feedback, you won't be able to say the words correctly. When you write with a pen, you're mostly unaware of the sensors telling you how to move it," she added.
It is not feasible to visualize the touch pathways in the human brain at high resolutions. So, Dr Wang and her collaborators from the University of Tsukuba in Japan and the Friedrich Miescher Institute for Biomedical Research in Switzerland used the whiskers of laboratory mice to map how distinct sensor neurons, presumably detecting different mechanical stimuli, are connected to signal the brain. When the sensory neurons are activated, they send the signal along an axon- a long, slender nerve fiber than conducts electric impulses to the brain. The researchers traced signals running the long path from the mouse's whiskers to the brain.