Updated on 6 May 2013
Singapore: US-based Regeneron Pharmaceuticals has acquired exclusive rights to two families of novel antibodies from Sanofi. Regeneron acquired full rights to antibodies targeting the PDGF (platelet derived growth factor) family of receptors and ligands in ophthalmology and all other indications.
It also received rights to antibodies targeting the ANG2 (angiopoietin2) receptor and ligand in ophthalmology. Antibodies to PDGF and ANG2 are currently in preclinical development for use in ophthalmology.
Regeneron will pay Sanofi $10 million upfront, up to $40 million in development milestone payments and royalties on sales for PGDF antibodies. With regards to ANG2, Regeneron will pay Sanofi $10 million upfront, a potential $5 million development milestone payment and royalties on sales.
Antibodies to ANG2 outside of ophthalmology will continue to be developed by Regeneron and Sanofi under their antibody collaboration agreement, including REGN910 (SAR 307746), an antibody to ANG2 that is currently in phase I development in patients with advanced malignancies.