One of the challenges in the R&D of next generation vaccines is the development of a delivery technology that will be more efficient, effective and safer than the conventional methods. Vaxxas, an Australian start-up founded in 2011, is working on one such technology.

Its platform technology Nanopatch, which emerged from the lab of Professor Mark Kendall's research group at the Australian Institute of Bioengineering and Nanotechnology at The University of Queensland, promises needle-free vaccine delivery that is quicker and more effective than conventional injections. It is a small silicon patch (1x1cm) that has tens of thousands of projections that are 200-300 microns in length.

"When you look at the Nanopatch, the projections are invisible to the naked eye. Vaccines are applied onto the Nanopatch in liquid form and then dried down, leaving the active components in a thermostable form on the tips of the projections," explains Mr David Hoey, who was recently appointed the company's first CEO. He added that the technology has "tremendous potential to improve the performance of a wide range of existing and new vaccines".

The University of Queensland's main commercialization arm, UniQuest, led the initial commercialization of the Nanopatch technology prior to the creation of Vaxxas in 2011. The first financing was in August 2011, where the company raised approximately $15.3 million (A$15 million) from a group of venture investors, including OneVentures, Brandon Capital, Healthcare Ventures, and the Medical Research Commercialisation Fund.

The Nanopatch is applied using a small spring loaded applicator that taps the Nanopatch onto the skin. It is painless and needs to be left in place for just two minutes and then removed. During the application process, the vaccine antigens are deposited directly in contact with the very dense populations of immune cells that reside just below the surface of the skin, provoking a very potent immune response. Mr Hoey says in a wide range of preclinical studies, it has been shown that the Nanopatch is so efficient in activating the immune response that as little as 1/100th of the dose delivered by Nanopatch can result in the same immune response as "full" dose by intramuscular injection.