Updated on 15 March 2013
Nanopatch is a small silicon patch (1x1cm) that has thousands of projections of 200-to-300 microns in length and invisible to the naked eye. Vaccines are applied onto the nanopatch in liquid form and then dried down, leaving the active components in a thermostable form on the tips of the projections.
The manufactured patches are coated with a formulation containing the vaccine. Coating method is optimized to be scalable and efficiently apply coating formulations rapidly with minimal wastage.
Nanopatch is applied using a small spring loaded applicator that "taps" the nanopatch onto the skin. The nanopatch is left in place for two minutes and then removed. During the application process, the vaccine antigens are deposited directly in contact with the very dense population of immune cells that reside just below the surface of the skin, provoking a very potent immune response.
In a wide range of preclinical studies, it has been shown that the nanopatch is so efficient in activating the immune response that as little as 1/100th of the dose delivered by nanopatch can result in the same immune response as "full" dose by intramuscular injection.
Moreover, it is induced with dry-coating technology that eliminates the need for vaccine refrigeration during storage and transportation, removing the resource burden of maintaining the cold chain.