PATH is also working with collaborators on low-cost solar refrigerators that do not require batteries and smart refrigerators that keep vaccines cold and yet shield them from freezing. Both the technologies aim to make refrigeration more affordable to facilitate immunization services in remote settings.

To help countries better manage their supply chain, PATH has also developed a Microsoft Access-based software tool called Cold Chain Equipment Manager (CCEM). The tool helps vaccination programs manage equipment requirements down to the facility level, forecast equipment needs for different scenarios, and generate procurement lists according to national policies. The CCEM differs from other available equipment management tools because, in addition to the usual data management, analysis, and reporting functions of a conventional inventory, it allows countries to view the cost and logistical implications of potential programmatic changes through "what if" scenarios.
By adopting new technologies, organizations have been able to ensure that besides developing safe and effective vaccines, they are transported to the right places at the right time and in the right condition.