Updated on 3 October 2012
Anti-CD19 monoclonal antibody
Novel biologics entity GBR 401 is an anti-CD19 monoclonal antibody developed by Glenmark Pharmaceuticals targeting Lymphomas and Leukemia's of B-cell origin. Lymphomas are cancers originating from the lymphatic system. CD19 also holds target potential for treatment of inflammatory disorders, such as rheumatoid arthritis.
Glenmark hopes to emerge GBR 401 as a valuable therapeutic option to treat patients affected with B-cell malignancies. GBR 401 has demonstrated strong anti-tumour potency and anti-proliferative apoptotic activity in several in-vitro and in-vivo studies. Glenmark is pursuing further development of GBR 401 to accelerate its entry into clinical stage. Antibody inhibitors or cytotoxic antibodies against CD19 have the potential to treat B cell or antibody-mediated diseases, including malignancies and autoimmune diseases. CD19 forms part of the B cell co-receptor in conjunction with CD81 and CD21.
Human anti-angiogenic monoclonal antibody
PharmAbcine, a spin-off company from Korea Research Institute of Bioscience and Biotechnology, is developing Tanibirumab (TTAC-0001), a fully human anti-angiogenic monoclonal antibody against VEGFR-2. The antibody has shown potent anti-angiogenic efficacy against various cancer-involved experiments as well as cross-species cross reactivity in mouse model.
Tanibirumab is in phase I stage with 5th cohort patients. The company will possibly complete its phase I within this year or early next year. PharmAbcine believes that characteristics of Tanibirumab hold reasonable promise of being successful as therapeutics.